Correlation of Perineural Invasion with Biochemical Recurrence and Negative Pathological Features in Prostate Adenocarcinoma View PDF

^*Seyma Ozkanli
Department Of Pathology, Istanbul Medeniyet University, Turkey

^*Corresponding Author:

Seyma Ozkanli
Department Of Pathology, Istanbul Medeniyet University, Turkey
Email:seymaozkanli@gmail.com

Published on: 2014-10-09

Abstract

Perineural invasion is regarded as a significant pathological feature in many organ cancers and a poor prognosis symptom for most of these cancers. In this study, our aim is to analyze the significance of perineural invasion independently from factors such as preoperative Gleason score and clinical, and with regard to biochemical recurrence that occurs after radical prostatectomy.

Keywords

Prostate; Perineural invasion; Biochemical recurrence; Seminal vesicle invasion; Radical Prostatectomy

Introduction

Autonomic innervation plays a crucial role in the development and maturation of the prostate gland. In prostate cancer, perineural invasion (PNI) is the interference between the neural cells and epithelial cells. The peripheral nerve sheath is composed of three layers: the epineurium, perineurium, and endoneurium. PNI is identified as the incidence of tumor cells in any of these layers and their extension through neural tracts.